The story of precision medicine in ARDS – Professor Carolyn Calfee Artwork

Asia Ventilation Forum

The Asia Ventilation Forum (AVF) is a not-for-profit organisation comprising members from different Asian countries. We share our knowledge and experience in respiratory care and critical care with intensive care unit (ICU) workers across the continent with the aim of improving care and outcomes for the critically ill. There are two AVF Podcast series. "Behind-The-Scenes ICU Stories" invites colleagues to share anything and everything on their personal experiences. Expect heart-to-heart discussions on topics that may or may not have been widely described in the medical literature. "The Challenges of Airway Management During the Pandemic" invites colleagues to share anything and everything on how they deal with various clinical situations. Expect discussions on how experts personalise evidence-based medicine for the patient at the bedside. These Podcasts are hosted by Dr Jason Phua, respiratory physician and intensivist at Alexandra Hospital, National University Health System, Singapore, and Dr Jose Emmanuel Palo, intensivist at The Medical City, the Philippines.

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Asia Ventilation Forum

The story of precision medicine in ARDS – Professor Carolyn Calfee

October 10, 2022 • AVF • Season 1 • Episode 23

In this AVF Podcast: Behind-The-Scenes ICU Stories episode, Professor Carolyn Calfee shares her journey on and discusses the science behind precision medicine in the acute respiratory distress syndrome (ARDS) and intensive care. Dr Calfee is Professor in Residence of Medicine and Anesthesia at the University of California, San Francisco (UCSF), where she attends in the intensive care units (ICUs) at Moffitt-Long Hospital. Her primary academic focus is the prevention, diagnosis, prognosis, and treatment of ARDS, and she is a key international leader with multiple high impact publications on molecular phenotyping of ARDS and precision medicine in the ICU.

Issues discussed in this interview:

• What precision medicine is

• The rationale for precision medicine in ARDS

• How Dr Calfee entered this field of research

• Selected landmark studies that reflect the potential of precision medicine in ARDS

• Challenges to overcome

• Implications for practising clinicians today

Selected further reading:

1. Beitler JR, Thompson BT, Baron RM, et al. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med 2022;10:107-20.

2. Bos LDJ, Artigas A, Constantin JM, et al. Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research. Eur Respir Rev 2021;30.

3. Reddy K, Sinha P, O'Kane CM, Gordon AC, Calfee CS, McAuley DF. Subphenotypes in critical care: translation into clinical practice. Lancet Respir Med 2020;8:631-43.

4. Sinha P, Delucchi KL, Thompson BT, et al. Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study. Intensive Care Med 2018;44:1859-69.

5. Calfee CS, Delucchi KL, Sinha P, et al. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med 2018;6:691-8.

6. Famous KR, Delucchi K, Ware LB, et al. Acute respiratory distress syndrome subphenotypes respond differently to randomized fluid management strategy. Am J Respir Crit Care Med 2017;195:331-8.

7. Calfee CS, Delucchi K, Parsons PE, et al. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med 2014;2:611-20.