How we studied sepsis in Asian ICUs – Dr Andrew Li Artwork

Asia Ventilation Forum

The Asia Ventilation Forum (AVF) is a not-for-profit organisation comprising members from different Asian countries. We share our knowledge and experience in respiratory care and critical care with intensive care unit (ICU) workers across the continent with the aim of improving care and outcomes for the critically ill. There are two AVF Podcast series. "Behind-The-Scenes ICU Stories" invites colleagues to share anything and everything on their personal experiences. Expect heart-to-heart discussions on topics that may or may not have been widely described in the medical literature. "The Challenges of Airway Management During the Pandemic" invites colleagues to share anything and everything on how they deal with various clinical situations. Expect discussions on how experts personalise evidence-based medicine for the patient at the bedside. These Podcasts are hosted by Dr Jason Phua, respiratory physician and intensivist at Alexandra Hospital, National University Health System, Singapore, and Dr Jose Emmanuel Palo, intensivist at The Medical City, the Philippines.

All Episodes

Asia Ventilation Forum

How we studied sepsis in Asian ICUs – Dr Andrew Li

January 04, 2023 • AVF • Season 1 • Episode 24

In this AVF Podcast: Behind-The-Scenes ICU Stories episode, Dr Andrew Li discusses MOSAICS II, the largest ever study on sepsis in Asian ICUs, and one that was completed before the COVID-19 pandemic. Dr Li is the lead author of the MOSAICS II study, and a consultant respiratory physician and intensivist from Singapore’s National University Hospital and Woodlands Health.

Issues discussed in this interview:

· Key findings of the MOSAICS II study

· Brief comparison with the MOSAICS I study published in 2011

· Challenges and rewards from multinational research collaboration

Selected further reading:

1. Li A, Ling L, Qin H, et al. Epidemiology, management, and outcomes of sepsis in ICUs among countries of differing national wealth across Asia. Am J Respir Crit Care Med 2022;206:1107-1116.

2. Phua J, Koh Y, Du B, et al. Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study. BMJ 2011;342:d3245.

3. Vincent JL, Sakr Y, Singer M, et al. Prevalence and outcomes of infection among patients in intensive care units in 2017. JAMA 2020;323:1478-1487.

4. Phua J, Faruq MO, Kulkarni AP, et al. Critical care bed capacity in Asian countries and regions. Crit Care Med 2020;48:654-662.